Viktoria Dorfer gave a talk at the MidWinter Proteomics Bioinformatics Seminar in Semmering, Austria, which took place from 13th to 16th of January, 2015. A lot of great people joined the meeting and the lively discussions on hot stuff in proteomics research; topics ranged from remaining issues on FDR calculation to re-analyzing the complete human proteome. A very exciting meeting!