MS Andrea
Researchers
Prof.(FH) DI(FH) Dr. Viktoria Dorfer MSc.
Prof.(FH) PD DI Dr. Stephan Winkler
Louise Buur MSc.
Duration
Research Areas
Partners
Anaxomics Biotech S.L., Barcelona, Spain
Centre for Genomic Regulation (CRG), Barcelona, Spain
Centre National De La Recherche Scientifique (CNRS-IPBS), Toulouse, France
Eberhard Karls University Tübingen (EKUT), Tübingen, Germany
Flemish Institute for Biotechnology (VIB), Ghent, Belgium
Max Planck Institute of Biochemistry (MPIB), Martinsreid, Germany
National Center for Genomic Analysis (CNAG), Barcelona, Spain
Tampere University (TAU), Tampere, Finland
Thermo Fisher Scientific, Bremen, Germany
Technical University of Munich (TUM), Munich, Germany
University of Southern Denmark (SDU), Odense, Denmark
University of Applied Sciences Upper Austria, Hagenberg Campus, RG Bioinformatics
Researchfocus
PROTrEIN is a European innovative and interdisciplinary research and training network to train the next generation of researchers in computational proteomics. The network consists of experts on network biology, (computational) proteomics, data visualization mass spectrometry and gamification from prestigious academic and non-academic institutions all over Europe. 15 early stage researchers are working on individual projects covering different aspects of computational proteomics such as novel machine learning predictors, new algorithms for data processing as well as integration with other omics fields, visualization, dissemination and communication.
The project of our group focuses on developing a new algorithm for peptide identification called MS Andrea. Using an open modification search strategy MS Andrea will be able to identify post-translationally modified peptides in a fast and effective way. However, one of the challenges of open modification search is the very large search space that comes with considering hundreds of modifications at once. This can increase the possibility of getting false positive hits and lengthy computation times. MS Andrea addresses this challenge by extracting sequence tags from each spectrum to reduce the number of peptide candidates to be matched and scored. MS Andrea is currently still under development, but we aim to release the first version in the fall of 2024.
You can read more about PROTrEIN and this project at https://protrein.eu/.
