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MS Andrea

Researchers

Prof.(FH) DI(FH) Dr. Viktoria Dorfer MSc.

Prof.(FH) PD DI Dr. Stephan Winkler

Louise Buur MSc. 


Duration

2021 – present

Research Areas

Proteomics

Partners

Anaxomics Biotech S.L., Barcelona, Spain

Centre for Genomic Regulation (CRG), Barcelona, Spain

Centre National De La Recherche Scientifique (CNRS-IPBS), Toulouse, France

Eberhard Karls University Tübingen (EKUT), Tübingen, Germany

Flemish Institute for Biotechnology (VIB), Ghent, Belgium

Max Planck Institute of Biochemistry (MPIB), Martinsreid, Germany

National Center for Genomic Analysis (CNAG), Barcelona, Spain

Tampere University (TAU), Tampere, Finland

Thermo Fisher Scientific, Bremen, Germany

Technical University of Munich (TUM), Munich, Germany

University of Southern Denmark (SDU), Odense, Denmark

University of Applied Sciences Upper Austria, Hagenberg Campus, RG Bioinformatics


Researchfocus

Proteomics

PROTrEIN is a European innovative and interdisciplinary research and training network to train the next generation of researchers in computational proteomics. The network consists of experts on network biology, (computational) proteomics, data visualization mass spectrometry and gamification from prestigious academic and non-academic institutions all over Europe. 15 early stage researchers are working on individual projects covering different aspects of computational proteomics such as novel machine learning predictors, new algorithms for data processing as well as integration with other omics fields, visualization, dissemination and communication. 

The project of our group focuses on developing a new algorithm for peptide identification called MS Andrea. Using an open modification search strategy MS Andrea will be able to identify post-translationally modified peptides in a fast and effective way. However, one of the challenges of open modification search is the very large search space that comes with considering hundreds of modifications at once. This can increase the possibility of getting false positive hits and lengthy computation times. MS Andrea addresses this challenge by extracting sequence tags from each spectrum to reduce the number of peptide candidates to be matched and scored. MS Andrea is currently still under development, but we aim to release the first version in the fall of 2024. 

You can read more about PROTrEIN and this project at https://protrein.eu/.