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Crosslink search engine MS Annika 3.0 published


Micha and Viki are happy to announce that MS Annika 3.0 – our crosslink search engine – has been published in Communications Chemistry. Crosslinking mass spectrometry enables the structural analysis of proteins and protein complexes and serves as a powerful tool in protein-protein interaction studies, however, the data analysis of large non-cleavable crosslink studies remains challenging. In this publication we introduce MS Annika 3.0, an algorithm for proteome-wide identification of non-cleavable crosslinks showing high sensitivity, accurate FDR estimation and computational performance, uncovering the structure of the C. elegans Box C/D complex.

More information can be found here: https://www.nature.com/articles/s42004-024-01386-x